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Moderate to severe proctitis of any etiology. Estimated Primary Completion Date :. Listing a study does not mean it has been evaluated by the U. Injured, inflamed or any significant disease in the peri-anal skin. No Intervention: Off treatment 2 week period without intervention. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Help guide our efforts to modernize ClinicalTrials. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Have done sigmoidsocopy or colonoscopy and anal manometry within five year of screening visit Exclusion Criteria: Advanced full thickness rectal prolapse.

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